Multifactorial resistance mechanisms associated with resistance to ceftazidime-avibactam in clinical <i>Pseudomonas aeruginosa</i> isolates from Switzerland.

ABSTRACT:

Background

Increasing reports of multidrug resistance (MDR) in clinical Pseudomonas aeruginosa have led to a necessity for new antimicrobials. Ceftazidime-avibactam (CZA) is indicated for use against MDR P. aeruginosa across a broad range of infection types and particularly those that are carbapenem resistant. This study sought to determine the molecular mechanisms of CZA and imipenem (IPM)-resistance in clinical P. aeruginosa isolates obtained from Swiss hospitals.

Methods

Clinical P. aeruginosa isolates were obtained from inpatients in three hospitals in Switzerland. Susceptibility was determined by either antibiotic disc testing or broth microdilution according to EUCAST methodology. AmpC activity was determined using cloxacillin and efflux act

SUBMITTER: Babouee Flury B 

PROVIDER: S-EPMC10166991 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature