Fecal and serum metabolomic signatures and gut microbiota characteristics of allergic rhinitis mice model.

ABSTRACT:

Background

The etiology of allergic rhinitis (AR) is complicated. Traditional therapy of AR still has challenges, such as low long-term treatment compliance, unsatisfactory therapeutic outcomes, and a high financial burden. It is urgent to investigate the pathophysiology of allergic rhinitis from different perspectives and explore brand-new possible preventative or treatment initiatives.

Objective

The aim is to apply a multi-group technique and correlation analysis to explore more about the pathogenesis of AR from the perspectives of gut microbiota, fecal metabolites, and serum metabolism.

Methods

Thirty BALB/c mice were randomly divided into the AR and Con(control) groups. A standardized Ovalbumin (OVA)-induced AR mouse model was established by intraperitoneal OVA in

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10167002 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature