3D histopathology of stenotic aortic valve cusps using ex vivo microfocus computed tomography.

ABSTRACT:

Background

Calcific aortic stenosis (AS) is the most prevalent heart valve disease in developed countries. The aortic valve cusps progressively thicken and the valve does not open fully due to the presence of calcifications. In vivo imaging, usually used for diagnosis, does not allow the visualization of the microstructural changes associated with AS.

Methods

Ex vivo high-resolution microfocus computed tomography (microCT) was used to quantitatively describe the microstructure of calcified aortic valve cusps in full 3D. As case study in our work, this quantitative analysis was applied to normal-flow low-gradient severe AS (NF-LG-SAS), for which the medical prognostic is still highly debated in the current literature, and high-gradient severe AS (HG-SAS).

Res

SUBMITTER: Pestiaux C 

PROVIDER: S-EPMC10167041 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature