Necrosis score as a prognostic factor in stage I-III colorectal cancer: a retrospective multicenter study.

ABSTRACT:

Background

Tumor necrosis results from failure to meet the requirement for rapid proliferation of tumor, related to unfavorable prognosis in colorectal cancer (CRC). However, previous studies used traditional microscopes to evaluate necrosis on slides, lacking a simultaneous phase and panoramic view for assessment. Therefore, we proposed a whole-slide images (WSIs)-based method to develop a necrosis score and validated its prognostic value in multicenter cohorts.

Methods

Necrosis score was defined as the proportion of necrosis in the tumor area, semi-quantitatively classified into 3-level score groups by the cut-off of 10% and 30% on HE-stained WSIs. 768 patients from two centers were enrolled in this study, divided into a discovery (N = 445) and a validation (N = 323) cohor

SUBMITTER: Ye H 

PROVIDER: S-EPMC10167085 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature