A fast computational model for circulatory dynamics: effects of left ventricle-aorta coupling.

ABSTRACT: The course of diseases such as hypertension, systolic heart failure and heart failure with a preserved ejection fraction is affected by interactions between the left ventricle (LV) and the vasculature. To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory system is presented. In a four-chamber model of the heart, the LV is represented by a previously described low-order, wall volume-preserving model that includes torsion and base-to-apex and circumferential wall shortening and lengthening, and the other chambers are represented using spherical geometries. Active and passive myocardial mechanics of all four chambers are included. The cardiac model is coupled with a wave propagation model for the aorta and a closed lumped-paramet

SUBMITTER: Moulton MJ 

PROVIDER: S-EPMC10167185 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature