Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder.

ABSTRACT: Epigenetic modifications occur sequentially during the lifespan, but their pace can be altered by external stimuli. The onset of schizophrenia and bipolar disorder is critically modulated by stressors that may alter the epigenetic pattern, a putative signature marker of exposure to environmental risk factors. In this study, we estimated the age-related epigenetic modifications to assess the differences between young individuals at familial high risk (FHR) and controls and their association with environmental stressors. The sample included 117 individuals (6-17 years) at FHR (45%) and a control group (55%). Blood and saliva samples were used estimate the epigenetic age with six epigenetic clocks through methylation data. Environmental risk was measured with obstetric complications, socioeco

SUBMITTER: Segura AG 

PROVIDER: S-EPMC10167217 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature