Risk of cardiac-related death in astrocytoma patients treated with chemotherapy: A competing risk analysis using the SEER database.

ABSTRACT:

Purpose

To explore the impact of chemotherapy on the risk of cardiac-related death in astrocytoma patients.

Methods

We retrospectively evaluated astrocytoma patients diagnosed between 1,975 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. Using Cox proportional hazards models, we compared the risks of cardiac-related death between a chemotherapy group and non-chemotherapy group. Competing-risks regression analyses were used to evaluate the difference in cardiac-related death. Also, propensity score matching (PSM) was employed to reduce confounding bias. The robustness of these findings was evaluated by sensitivity analysis, and E values were calculated.

Results

A total of 14,834 patients diagnosed with astrocytoma were included. Chemotherap

SUBMITTER: Wang X 

PROVIDER: S-EPMC10167282 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature