Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis.

ABSTRACT:

Introduction

Inflammation is an inherently self-amplifying process, resulting in progressive tissue damage when unresolved. A brake on this positive feedback system is provided by the nervous system which has evolved to detect inflammatory signals and respond by activating anti-inflammatory processes, including the cholinergic anti-inflammatory pathway mediated by the vagus nerve. Acute pancreatitis, a common and serious condition without effective therapy, develops when acinar cell injury activates intrapancreatic inflammation. Prior study has shown that electrical stimulation of the carotid sheath, which contains the vagus nerve, boosts the endogenous anti-inflammatory response and ameliorates acute pancreatitis, but it remains unknown whether these anti-inflammatory signals orig

SUBMITTER: Thompson DA 

PROVIDER: S-EPMC10167283 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature