Supplementation with inulin-type fructans affects gut microbiota and attenuates some of the cardiometabolic benefits of a plant-based diet in individuals with overweight or obesity.

ABSTRACT:

Background

The gut microbiota has emerged as a potential therapeutic target to improve the management of obesity and its comorbidities.

Objective

We investigated the impact of a high fiber (∼38 g/d) plant-based diet, consumed ad libitum, with or without added inulin-type fructans (ITF), on the gut microbiota composition and cardiometabolic outcomes in subjects with obesity. We also tested if baseline Prevotella/Bacteroides (P/B) ratio predicts weight loss outcomes.

Methods

This is a secondary exploratory analysis from the PREVENTOMICS study, in which 100 subjects (82 completers) aged 18-65 years with body mass index 27-40 kg/m² were randomized to 10 weeks of double-blinded treatment with a personalized or a generic plant-based diet. Changes fr

SUBMITTER: Aldubayan MA 

PROVIDER: S-EPMC10167298 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature