Altered gut microbiota and microbial metabolism in children with hepatic glycogen storage disease: a case-control study.

ABSTRACT:

Background

Accumulating evidence has demonstrated that gut microbiota dysbiosis correlated with altered metabolism are implicated in liver metabolic diseases. However, data on pediatric hepatic glycogen storage disease (GSD) are limited. Here, we aimed to investigate the features of the gut microbiota and metabolites in hepatic GSD children from China.

Methods

Totals of 22 hepatic GSD patients and 16 age- and gender-matched healthy children were enrolled from the Shanghai Children's Hospital, China. Pediatric GSD patients were confirmed as having hepatic GSD via genetic diagnosis and/or liver biopsy pathology. The control group comprised children without any history of chronic diseases or clinically relevant GSD or symptoms of any other metabolic diseases. The baseline chara

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10167392 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature