Screening of key pathogenic genes of type 1 diabetes in children.

ABSTRACT:

Background

The etiology of type 1 diabetes mellitus (T1DM) in pediatric populations remains poorly understood. The key to precise prevention and treatment of T1DM in identifying crucial pathogenic genes. These key pathogenic genes can serve as biological markers for early diagnosis and classification, as well as therapeutic targets. However, there is currently a lack of relevant research on screening key pathogenic genes based on sequencing data and efficient algorithms.

Methods

The transcriptome sequencing results of peripheral blood mononuclear cells (PBMCs) of children with T1DM (GSE156035) were downloaded from the Gene Expression Omnibus (GEO) database. The data set contained 20 T1DM samples and 20 control samples. Differentially expressed genes (DEGs) in children with T

SUBMITTER: Zhan S 

PROVIDER: S-EPMC10167398 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature