Cryoablation inhibits the recurrence and progression of bladder cancer by enhancing tumour-specific immunity.

ABSTRACT:

Background

Recurrence and metastasis of bladder cancer are major factors affecting patient prognosis. Endoscopic cryoablation achieved a better clinical outcome among clinical patients and could be synergistic with ICIs. Thus, this study aimed to evaluate the immunological mechanism of cryoablation for bladder cancer to reveal the therapeutic mechanism.

Methods

We systematically reviewed the clinical prognosis of patients underwent cryoablation at Huashan Hospital in these first-in-human studies (ChiCTR-INR-17013060). Murine models were constructed to explore cryoablation-induced tumour-specific immunity, which was further confirmed by primary bladder tumour organoids and autologous lymphocytes cocultured system.

Results

Cryoablation improved progression-free survival

SUBMITTER: Mou Z 

PROVIDER: S-EPMC10167412 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature