Impact of tumour region of interest delineation method for mid-treatment FDG-PET response prediction in head and neck squamous cell carcinoma undergoing radiotherapy.

ABSTRACT:

Background

The aim of this study was to evaluate the impact of tumour region of interest (ROI) delineation method on mid-treatment ¹⁸F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) response prediction in mucosal head and neck squamous cell carcinoma during radiotherapy.

Methods

A total of 52 patients undergoing definitive radiotherapy with or without systemic therapy from two prospective imaging biomarker studies were analysed. FDG-PET was performed at baseline and during radiotherapy (week 3). Primary tumour was delineated using a fixed SUV 2.5 threshold (MTV2.5), relative threshold (MTV40%) and a gradient based segmentation method (PET Edge). PET parameters SUV_max, SUV_mean, metabolic tumour volume (MTV) and total lesion gl

SUBMITTER: Trada Y 

PROVIDER: S-EPMC10167452 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature