Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease.

ABSTRACT:

Importance

Longitudinal tau positron emission tomography (PET) is a relevant outcome in clinical trials evaluating disease-modifying therapies in Alzheimer disease (AD). A key unanswered question is whether the use of participant-specific (individualized) regions of interest (ROIs) is superior to conventional approaches where the same ROI (group-level) is used for each participant.

Objective

To compare group- and participant-level ROIs in participants at different stages of the AD clinical continuum in terms of annual percentage change in tau-PET standardized uptake value ratio (SUVR) and sample size requirements.

Design, setting, and participants

This was a longitudinal cohort study with consecutive participant enrollment between September 18, 2017, and November 15,

SUBMITTER: Leuzy A 

PROVIDER: S-EPMC10167602 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature