Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults.

ABSTRACT: Higher physical activity levels are associated with reduced cognitive decline among older adults; however, current understanding of underlying brain mechanisms is limited. This cross-sectional study investigated the relationship between actigraphy-estimated total volume of physical activity (TVPA) and magnetic resonance imaging (MRI) measures of white matter hyperintensities (WMH), and functional and structural brain connectivity, measured by resting-state functional MRI and diffusion tensor imaging. Study participants (N = 156, mean age = 71 years) included 136 with normal cognition and 20 with Mild Cognitive Impairment. Higher TVPA was associated with greater functional connectivity within the default-mode network and greater network modularity (a measure of network specialization), as w

SUBMITTER: Soldan A 

PROVIDER: S-EPMC10167793 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature