Distinct profiles of oxylipid mediators in liver, lung, and placenta after maternal nano-TiO₂ nanoparticle inhalation exposure.

ABSTRACT: Nano-titanium dioxide (nano-TiO₂) is a widely used nanomaterial found in several industrial and consumer products, including surface coatings, paints, sunscreens and cosmetics, among others. Studies have linked gestational exposure to nano-TiO₂ with negative maternal and fetal health outcomes. For example, maternal pulmonary exposure to nano-TiO₂ during gestation has been associated not only with maternal, but also fetal microvascular dysfunction in a rat model. One mediator of this altered vascular reactivity and inflammation is oxylipid signaling. Oxylipids are formed from dietary lipids through several enzyme-controlled pathways as well as through oxidation by reactive oxygen species. Oxylipids have been linked to control of vascular tone, inflammation,

SUBMITTER: Harris TR 

PROVIDER: S-EPMC10167894 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature