Sympathomimetic increases resting energy expenditure following bariatric surgery: A randomized controlled clinical trial.

ABSTRACT:

Objective

The aim of this study was to test the hypothesis that ephedrine + caffeine (EC) reduces the fall in resting energy expenditure (REE) following bariatric surgery.

Methods

This 32-week, randomized, double-blinded, placebo-controlled trial included 142 patients who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery. Participants were randomized to either EC or placebo for 27 weeks, beginning 5 weeks post surgery. The primary end points were change in REE (measured), percentage of predicted REE ([measured REE/Harris-Benedict equation-predicted REE] × 100), and body composition. Secondary outcomes included change in percentage of weight. Adverse events (AEs) were recorded.

Results

The reduction in REE was smaller in the EC versus the pla

SUBMITTER: Rebello CJ 

PROVIDER: S-EPMC10167942 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature