Subconjunctival Sirolimus-Loaded Liposomes for the Treatment of Moderate-to-Severe Dry Eye Disease.

ABSTRACT:

Purpose

To determine the effectiveness of subconjunctival application of a novel sirolimus liposomal formulation for the treatment of dry eye.

Methods

A randomized, triple-blind, Phase II clinical trial. Thirty-eight eyes of 19 patients were included. Nine patients (18 eyes) assigned to the sham group (Sham) and 10 patients (20 eyes) to sirolimus-loaded liposomes group (Sirolimus). The treatment group received three doses of subconjunctival liposome-encapsulated sirolimus and the sham group received three doses of liposomal suspension without sirolimus. Subjective (Ocular Surface Disease Index, OSDI) and measured (corrected distance visual acuity, conjunctival hyperemia, tear osmolarity, Schirmer's test, corneal/conjunctival staining and matrix metalloproteinase-9) variables

SUBMITTER: Salcedo-Ledesma A 

PROVIDER: S-EPMC10167993 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature