Gastric juice microbiota in pediatric chronic gastritis that clinically tested positive and negative for Helicobacter pylori.

ABSTRACT:

Purpose

Helicobacter pylori (HP) infection is an identified risk factor for pediatric chronic gastritis (PCG), but its impact on gastric juice microbiota (GJM) remains to be further elucidated in PCG. This study aimed to analyze and compare the microbial communities and microbial interactive networks of GJM in PCG that clinically tested positive and negative for HP (HP+ and HP-, respectively).

Methods

A total of 45 PCG patients aged from 6 to 16 years were recruited, including 20 HP+ and 25 HP- patients tested by culture and rapid urease test. Gastric juice samples were collected from these PCG patients and subjected to high-throughput amplicon sequencing and subsequent analysis of 16S rRNA genes.

Results

While no significant change in alpha diversity, signific

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10168005 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature