A Nasal Aerodynamics Perspective of Retronasal Olfaction: Rodents vs. Humans.

ABSTRACT:

Introduction

Odor perception can be achieved through ortho or retronasal routes, with the latter being an important component of flavor perception. There are significant olfactory differences that exist between rats and humans and by understanding the role of structural differences, further insight can be gained into the mechanism of odorant perception via ortho or retronasal routes.

Methods

3D human and rat (Sprague Dawley) computational models were used to investigate nasal anatomy impact on ortho vs. retronasal odorant transport to the olfactory epithelium. The nasal pharynx region was modified for human and rat models to probe nasal structure impact on ortho vs retro olfaction. 65 odorant absorption rates to the olfactory epithelium were extracted from each model.

Res

SUBMITTER: Kim K 

PROVIDER: S-EPMC10168102 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature