New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders.

ABSTRACT: Nitrosyl ruthenium complexes are promising platforms for nitric oxide (NO) and nitroxyl (HNO) release, which exert their therapeutic application. In this context, we developed two polypyridinic compounds with the general formula cis-[Ru(NO)(bpy)₂(L)]ⁿ⁺, where L is an imidazole derivative. These species were characterized by spectroscopic and electrochemical techniques, including XANES/EXAFS experiments, and further supported by DFT calculations. Interestingly, assays using selective probes evidenced that both complexes can release HNO on reaction with thiols. This finding was biologically validated by HIF-1α detection. The latter protein is related to angiogenesis and inflammation processes under hypoxic conditions, which is selectively destabilized by n

SUBMITTER: Gouveia Junior FS 

PROVIDER: S-EPMC10168103 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature