Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning.

ABSTRACT:

Background

The ε4 allele of the apolipoprotein (APOE) gene and posttraumatic stress disorder (PTSD) are associated with cognitive deficits. Both associations may vary depending on age. No previous study has examined a possible three-way interaction between APOE ε4, PTSD, and age on cognitive functioning.

Methods

Data were analyzed from 1244 European-American U.S. military veterans who participated in the 2011 National Health and Resilience in Veterans Study (NHRVS). Analyses of covariance were used to examine the main effects and interactions of APOE ε4, PTSD, and age on learning/working memory (LWM) and attention/psychomotor (APM) performance.

Results

A significant three-way interaction between APOE ε4, PTSD, and age on the LWM composite (η_p ²  

SUBMITTER: Lawrence KA 

PROVIDER: S-EPMC10168127 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature