CD3⁺ T-cell: CD14⁺monocyte complexes are dynamic and increased with HIV and glucose intolerance.

ABSTRACT: An increased risk of cardiometabolic disease accompanies persistent systemic inflammation. Yet, the innate and adaptive immune system features in persons who develop these conditions remain poorly defined. Doublets, or cell-cell complexes, are routinely eliminated from flow cytometric and other immune phenotyping analyses, which limits our understanding of their relationship to disease states. Using well-characterized clinical cohorts, including participants with controlled HIV as a model for chronic inflammation and increased immune cell interactions, we show that circulating CD14⁺ monocytes complexed to CD3⁺ T cells are dynamic, biologically relevant, and increased in individuals with diabetes after adjusting for confounding factors. The complexes form functional im

SUBMITTER: Obare LM 

PROVIDER: S-EPMC10168203 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature