Understanding natural selection in Holocene Europe using multi-locus genotype identity scans.

ABSTRACT: Ancient DNA (aDNA) has been a revolutionary technology in understanding human history but has not been used extensively to study natural selection as large sample sizes to study allele frequency changes over time have thus far not been available. Here, we examined a time transect of 708 published samples over the past 7,000 years of European history using multi-locus genotype-based selection scans. As aDNA data is affected by high missingness, ascertainment bias, DNA damage, random allele calling, and is unphased, we first validated our selection scan, G12ancient, on simulated data resembling aDNA under a demographic model that captures broad features of the allele frequency spectrum of European genomes as well as positive controls that have been previously identified and functionally vali

SUBMITTER: Pandey D 

PROVIDER: S-EPMC10168228 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature