Propulsive cell entry diverts pathogens from immune degradation by remodeling the phagocytic synapse.

ABSTRACT: Phagocytosis is a critical immune function for infection control and tissue homeostasis. This process is typically described as non-moving pathogens being internalized and degraded in phagolysosomes. For pathogens that evade immune degradation, the prevailing view is that virulence factors that biochemically disrupt the biogenesis of phagoslysosomes are required. In contrast, here we report that physical forces exerted by pathogens during cell entry divert them away from the canonical phagolysosomal degradation pathway, and this altered intracellular fate is determined at the time of phagocytic synapse formation. We used the eukaryotic parasite Toxoplasma gondii as a model because live Toxoplasma uses gliding motility to actively invade into host cells. To differentiate the e

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10168248 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature