RNAvigate: Efficient exploration of RNA chemical probing datasets.

ABSTRACT: Chemical probing technologies enable high-throughput examination of diverse structural features of RNA including local nucleotide flexibility, RNA secondary structure, protein- and ligand-binding, through-space interaction networks, and multi-state structural ensembles. Performing these experiments, by themselves, does not directly lead to biological insight. Instead, deep understanding of RNA structure-function relationships typically requires evaluating a system under structure- and function-altering conditions, linking these data with additional information, and visualizing multi-layered relationships. Current platforms lack the broad accessibility, flexibility, and efficiency needed to iterate on integrative analyses of these diverse, complex data. Here, we share the RNA visualization

SUBMITTER: Irving PS 

PROVIDER: S-EPMC10168276 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature