Statistical learning in epilepsy: Behavioral, anatomical, and causal mechanisms in the human brain.

ABSTRACT: Statistical learning, the fundamental cognitive ability of humans to extract regularities across experiences over time, engages the medial temporal lobe in the healthy brain. This leads to the hypothesis that statistical learning may be impaired in epilepsy patients, and that this impairment could contribute to their varied memory deficits. In turn, epilepsy patients provide a platform to advance basic understanding of statistical learning by helping to evaluate the necessity of medial temporal lobe circuitry through disease and causal perturbations. We implemented behavioral testing, volumetric analysis of the medial temporal lobe substructures, and direct electrical brain stimulation to examine statistical learning across a cohort of 61 epilepsy patients and 28 healthy controls. Behavior

SUBMITTER: Aljishi A 

PROVIDER: S-EPMC10168289 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature