Computational Mechanobiology Model Evaluating Healing of Postoperative Cavities Following Breast-Conserving Surgery.

ABSTRACT: Breast cancer is the most commonly diagnosed cancer type worldwide. Given high survivorship, increased focus has been placed on long-term treatment outcomes and patient quality of life. While breast-conserving surgery (BCS) is the preferred treatment strategy for early-stage breast cancer, anticipated healing and breast deformation (cosmetic) outcomes weigh heavily on surgeon and patient selection between BCS and more aggressive mastectomy procedures. Unfortunately, surgical outcomes following BCS are difficult to predict, owing to the complexity of the tissue repair process and significant patient-to-patient variability. To overcome this challenge, we developed a predictive computational mechanobiological model that simulates breast healing and deformation following BCS. The coupled bioch

SUBMITTER: Harbin Z 

PROVIDER: S-EPMC10168325 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature