Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1/PD-L1 or CTLA4 have revolutionized cancer management but are associated with devastating immune-related adverse events (irAEs) including myocarditis. The main risk factor for ICI myocarditis is the use of combination PD-1 and CTLA4 inhibition. ICI-myocarditis is often fulminant and is pathologically characterized by myocardial infiltration of T lymphocytes and macrophages. While much has been learned regarding the role of T-cells in ICI-myocarditis, little is understood regarding the identity, transcriptional diversity, and functions of infiltrating macrophages.

Methods

We employed an established murine ICI myocarditis model ( Ctla4 ^+/- Pdcd1 ^-/- mice) to explore the cardia

SUBMITTER: Ma P 

PROVIDER: S-EPMC10168426 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature