Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization.

ABSTRACT: Large-scale functional networks have been characterized in both rodent and human brains, typically by analyzing fMRI-BOLD signals. However, the relationship between fMRI-BOLD and underlying neural activity is complex and incompletely understood, which poses challenges to interpreting network organization obtained using this technique. Additionally, most work has assumed a disjoint functional network organization (i.e., brain regions belong to one and only one network). Here, we employed wide-field Ca²⁺ imaging simultaneously with fMRI-BOLD in mice expressing GCaMP6f in excitatory neurons. We determined cortical networks discovered by each modality using a mixed-membership algorithm to test the hypothesis that functional networks are overlapping rather than disjoint. Our results

SUBMITTER: Vafaii H 

PROVIDER: S-EPMC10168440 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature