Selective effects of estradiol on human corneal endothelial cells.

ABSTRACT: Fuchs endothelial corneal dystrophy (FECD) results from genetic and environmental factors triggering mitochondrial and oxidative stress in corneal endothelial cells (CEnCs) leading to CEnC death and corneal opacification. FECD is more common in women than men, but the basis for this observation is unknown. Because FECD is commonly diagnosed around the time of the menopausal transition in women when estrogen levels decrease precipitously, we studied the effects of the potent estrogen,17-β estradiol (E2) on growth, oxidative stress, and metabolism in primary cultures of human CEnCs (HCEnCs) under conditions of physiologic 2.5% O ₂ ([O ₂ ] _2.5 ) and under hyperoxic stress ([O ₂ ] _A : room air + 5% CO ₂ ). We hypothesized that E

SUBMITTER: Han S 

PROVIDER: S-EPMC10168450 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature