Development and application of an algorithm for statin-induced myopathy based on electronic health record-derived structured elements.

ABSTRACT:

Objective

Considering the non-specific nature of muscle symptoms, studies of statin-induced myopathy (SIM) in electronic health records require accurate algortihms that can reliably identify true statin-related cases. However, prior algorithms have been constructed in study populations that preclude broad applicability. Here we developed and validated an algorithm that accurately defines SIM from electronic health records using structured data elements and conducted a study of determinants of SIM after applying the algorithm.

Materials and methods

We used electronic records from an integrated health care delivery system (including comprehensive pharmacy dispensing records) and defined SIM as elevated creatine kinase (CK) ≥4 x upper limit of normal. A diverse cohort of partic

SUBMITTER: Oni-Orisan A 

PROVIDER: S-EPMC10168492 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature