Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study.

ABSTRACT:

Background

Sex-related steroid hormones and proteins may contribute to the sex differences in the characteristics and health consequences of alcohol use disorder. This study aimed to examine the associations between alcohol dependence (AD) and sex-related hormones/proteins using a population-based dataset.

Methods

We retrieved serum total testosterone (TT) and estradiol (TE2), sex hormone binding globulin (SHBG), and albumin levels along with clinical data from the UK Biobank. Hormone/protein levels were compared between AD (lifetime AD and/or related diagnoses; 2218 males; 682 females) and control (no aforementioned diagnoses and AUDIT<8; 198,058 males; 250,830 females) groups with sex-dependent linear regression models adjusting for age and body mass index. Moderation and

SUBMITTER: Ho AM 

PROVIDER: S-EPMC10168535 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature