Selective control of synaptic plasticity in heterogeneous networks through transcranial alternating current stimulation (tACS).

ABSTRACT: Transcranial alternating current stimulation (tACS) represents a promising non-invasive treatment for an increasingly wide range of neurological and neuropsychiatric disorders. The ability to use periodically oscillating electric fields to non-invasively engage neural dynamics opens up the possibility of recruiting synaptic plasticity and to modulate brain function. However, despite consistent reports about tACS clinical effectiveness, strong state-dependence combined with the ubiquitous heterogeneity of cortical networks collectively results in high outcome variability. Introducing variations in intrinsic neuronal timescales, we explored how such heterogeneity influences stimulation-induced change in synaptic connectivity. We examined how spike timing dependent plasticity, at the level of

SUBMITTER: Pariz A 

PROVIDER: S-EPMC10168590 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature