PET Imaging of Self-Assembled ¹⁸ F-Labelled Pd₂ L₄ Metallacages for Anticancer Drug Delivery.

ABSTRACT: To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of ¹⁸ F-labelled [Pd₂ L₄ ]⁴⁺ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

SUBMITTER: Cosialls R 

PROVIDER: S-EPMC10168593 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature