A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies.

ABSTRACT: Multicentric approaches are widely used in clinical trials to assess the generalizability of findings, however, they are novel in laboratory-based experimentation. It is unclear how multilaboratory studies may differ in conduct and results from single lab studies. Here, we synthesized the characteristics of these studies and quantitatively compared their outcomes to those generated by single laboratory studies. MEDLINE and Embase were systematically searched. Screening and data extractions were completed in duplicate by independent reviewers. Multilaboratory studies investigating interventions using in vivo animal models were included. Study characteristics were extracted. Systematic searches were then performed to identify single lab studies matched by intervention and disease. Difference

SUBMITTER: Hunniford VT 

PROVIDER: S-EPMC10168693 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature