Endoscopic calcium electroporation for colorectal cancer: a phase I study.

ABSTRACT: Background and study aims  Colorectal cancer is one of the most common malignancies, with approximately 20 % of patients having metastatic disease. Local symptoms from the tumor remain a common issue and affect quality of life. Electroporation is a method to permeabilize cell membranes with high-voltage pulses, allowing increased passage of otherwise poorly permeating substances such as calcium. The aim of this study was to determine the safety of calcium electroporation for advanced colorectal cancer. Patients and methods  Six patients with inoperable rectal and sigmoid colon cancer were included, all presenting with local symptoms. Patients were offered endoscopic calcium electroporation and were followed up with endoscopy and computed tomography/magnetic resonance scans. B

SUBMITTER: Broholm M 

PROVIDER: S-EPMC10169226 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature