ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma.

ABSTRACT:

Background

Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glioma. ZDHHC15, a member of the ZDHHCs family, participates in various physiological activities in the brain. However, the biological functions and related mechanisms of ZDHHC15 in glioma remain poorly understood.

Methods

Data from multiple glioma-associated datasets were used to investigate the expression profiles and potential biological functions of ZDHHC15 in glioma. Expression of ZDHHC15 and its association with clinicopathological characteristics in glioma were validated by quantitative reverse transcription PCR (RT-qPCR) and immunohistochemical experiment

SUBMITTER: Liu ZY 

PROVIDER: S-EPMC10169355 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature