Higher tacrolimus trough levels and time in the therapeutic range are associated with the risk of acute rejection in the first month after renal transplantation.

ABSTRACT:

Background

Tacrolimus trough levels (C₀) are used in most transplant centres for therapeutic drug monitoring (TDM) of tacrolimus (Tac). The target range of Tac C₀ has been remarkably changed, with a target as low as 3-7 ng/ml in the 2009 European consensus conference and a target of 4-12 ng/ml (preferably to 7-12 ng/ml) following the second consensus report in 2019. Our aim was to investigate whether reaching early Tac therapeutic targets and maintaining time in the therapeutic range (TTR) according to the new recommendations may be necessary for preventing acute rejection (AR) during the first month after transplantation.

Methods

A retrospective study including 160 adult renal transplant patients (113 men and 47 women) with a median age of 36.3 (20-44)

SUBMITTER: Nguyen TVA 

PROVIDER: S-EPMC10169362 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature