Dispensability of Ascorbic Acid Uptake and Utilization Encoded by ulaABCD for the Virulence of Haemophilus ducreyi in Humans.
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ABSTRACT:
SUBMITTER: Brothwell JA
PROVIDER: S-EPMC10169391 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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Dispensability of Ascorbic Acid Uptake and Utilization Encoded by ulaABCD for the Virulence of Haemophilus ducreyi in Humans.
Brothwell Julie A JA Fortney Kate R KR Batteiger Teresa T Katz Barry P BP Spinola Stanley M SM
The Journal of infectious diseases 20230201 3
Compared with wounded skin, ascorbic acid is enriched in pustules of humans experimentally infected with Haemophilus ducreyi. Compared with the broth-grown inocula, transcription of the H. ducreyi ulaABCD operon, which encodes genes for ascorbic acid uptake, is increased in pustules. We hypothesized that ascorbic acid uptake plays a role in H. ducreyi virulence. Five volunteers were infected with both H. ducreyi strain 35000HP and its isogenic ulaABCD deletion mutant at multiple sites; the papul ...[more]
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