The Nicaraguan Pediatric Influenza Cohort Study, 2011-2019: Influenza Incidence, Seasonality, and Transmission.

ABSTRACT:

Background

Children account for a large portion of global influenza burden and transmission, and a better understanding of influenza in children is needed to improve prevention and control strategies.

Methods

To examine the incidence and transmission of influenza we conducted a prospective community-based study of children aged 0-14 years in Managua, Nicaragua, between 2011 and 2019. Participants were provided with medical care through study physicians and symptomatic influenza was confirmed by reverse-transcription polymerase chain reaction (RT-PCR). Wavelet analyses were used to examine seasonality. Generalized growth models (GGMs) were used to estimate effective reproduction numbers.

Results

From 2011 to 2019, 3016 children participated, with an average of ∼1800 pa

SUBMITTER: Maier HE 

PROVIDER: S-EPMC10169406 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature