RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain.

ABSTRACT: Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly managed by current therapeutics. Here we focused on a unique group of neuropathic pain patients undergoing thoracic vertebrectomy where the dorsal root ganglia is removed as part of the surgery allowing for molecular characterization and identification of mechanistic drivers of neuropathic pain independently of preclinical models. Our goal was to quantify whole transcriptome RNA abundances using RNA-seq in pain-associated human dorsal root ganglia from these patients, allowing comprehensive identification of molecular changes in these samples by contrasting them with non-pain-associated dorsal root ganglia. We sequenced 70 human dorsal root ganglia, and among these 50 met inclusion criteria for suffic

SUBMITTER: Ray PR 

PROVIDER: S-EPMC10169414 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature