Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury.

ABSTRACT:

Background

Piperacillin/tazobactam, a commonly used antibiotic, is associated with acute kidney injury (AKI). The relationship between piperacillin concentrations and AKI remains unknown.

Objective

Estimate piperacillin exposures in critically ill children and young adults administered piperacillin/tazobactam to identify concentrations and clinical factors associated with piperacillin-associated AKI.

Patients and methods

We assessed piperacillin pharmacokinetics in 107 patients admitted to the paediatric ICU who received at least one dose of piperacillin/tazobactam. Piperacillin AUC, highest peak (Cmax) and highest trough (Cmin) in the first 24 hours of therapy were estimated. Piperacillin-associated AKI was defined as Kidney Disease: Improving Global Outcomes (KDIGO)

SUBMITTER: Tang Girdwood S 

PROVIDER: S-EPMC10169424 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature