Heroin Use Is Associated With Vascular Inflammation in Human Immunodeficiency Virus.

ABSTRACT:

Background

Heroin use may work synergistically with human immunodeficiency virus (HIV) infection to cause greater immune dysregulation than either factor alone. Unraveling how this affects end-organ disease is key as it may play a role in the excess mortality seen in people with HIV (PWH) who use heroin despite access to care and antiretroviral therapy.

Methods

This is a prospectively enrolled, cross-sectional study of adults with and without HIV who use and do not use heroin using (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) to compare tissue-specific inflammation including aortic (target-to-background ratio [TBR]), splenic, and bone marrow (standardized uptake value [SUV]).

Results

A total of 120 participants were enrolled

SUBMITTER: Hileman CO 

PROVIDER: S-EPMC10169434 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature