Multiple imputation methods for missing multilevel ordinal outcomes.

ABSTRACT:

Background

Multiple imputation (MI) is an established technique for handling missing data in observational studies. Joint modelling (JM) and fully conditional specification (FCS) are commonly used methods for imputing multilevel data. However, MI methods for multilevel ordinal outcome variables have not been well studied, especially when cluster size is informative on the outcome. The purpose of this study is to describe and compare different MI strategies for dealing with multilevel ordinal outcomes when informative cluster size (ICS) exists.

Methods

We conducted comprehensive Monte Carlo simulation studies to compare the performance of five strategies: complete case analysis (CCA), FCS, FCS+CS (including cluster size (CS) in the imputation model), JM, and JM+CS under vario

SUBMITTER: Dong M 

PROVIDER: S-EPMC10169455 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature