A novel prognostic signatures based on metastasis- and immune-related gene pairs for colorectal cancer.

ABSTRACT:

Background

Metastasis remains the leading cause of mortality in patients diagnosed with colorectal cancer (CRC). The pivotal contribution of the immune microenvironment in the initiation and progression of CRC metastasis has gained significant attention.

Methods

A total of 453 CRC patients from The Cancer Genome Atlas (TCGA) were included as the training set, and GSE39582, GSE17536, GSE29621, GSE71187 were included as the validation set. The single-sample gene set enrichment analysis (ssGSEA) was performed to assess the immune infiltration of patients. Least absolute shrinkage and selection operator (LASSO) regression analysis, Time-dependent receiver operating characteristic (ROC) and Kaplan-Meier analysis were used to construct and validate risk models based on R package.

SUBMITTER: Pan B 

PROVIDER: S-EPMC10169605 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature