Antibacterial and anti-biofilm activity of radezolid against Staphylococcus aureus clinical isolates from China.

ABSTRACT: Although the potent antibacterial ability of radezolid against Staphylococcus aureus has been widely reported worldwide, its antibacterial and anti-biofilm activity against the S. aureus clinical isolates from China remains elusive. In this study, the minimum inhibitory concentration (MIC) of radezolid was determined in S. aureus clinical isolates from China using the agar dilution method, and the relationship between radezolid susceptibility and ST distribution was also investigated. The anti-biofilm activity of radezolid against S. aureus was determined by a crystal violet assay and compared with that of linezolid and contezolid. The quantitative proteomics of S. aureus treated with radezolid was analyzed, and the genetic mutations in radezolid-induced

SUBMITTER: Wang C 

PROVIDER: S-EPMC10169660 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature