Immunological role and prognostic value of the SKA family in pan-cancer analysis.

ABSTRACT:

Background

The spindle and kinetochore associated (SKA) complex, which plays important roles in proper chromosome segregation during mitosis by maintaining the stabilization of kinetochore-spindle microtubule attachment during mitosis, has recently been reported to exert regulatory effects on the initiation and progression of various human cancer types. Nevertheless, the prognostic significance and immune infiltration of the SKA family across cancers have not been well elucidated.

Methods

Using data from three large public datasets, including The Cancer Genome Atlas, Genotype-Tissue Expression, and Gene Expression Omnibus databases, a novel scoring system (termed the SKA score) was developed to quantify the SKA family level across cancers. We then evaluated the prognostic im

SUBMITTER: Li Z 

PROVIDER: S-EPMC10169755 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature