Preoperative imaging for hyperparathyroidism often takes upper parathyroid adenomas for lower adenomas.

ABSTRACT: We retrospectively evaluated how accurately preoperative imaging localizes parathyroid adenoma in superior versus inferior parathyroids. Over 6 years, 104 patients with primary hyperparathyroidism underwent parathyroid surgery in a single centre. Of these, 103 underwent ultrasound, 97 [^99mTc]pertechnetate/MIBI SPECT/CT and 30 [¹⁸F]fluorocholine (FCH) PET/CT. One patient with a unilateral double adenoma was excluded from the analysis. Surgical findings with histopathologic confirmation of adenoma were used as the standard. Ultrasound misjudged 5 of 48 detected lower adenomas as upper, but 14 of 29 upper adenomas as lower (error rate 10 vs 48%, p = 0.0002). The corresponding error rates for [^99mTc]pertechnetate/MIBI SPECT/CT were 3 versus 55% (p = 0.000014),

SUBMITTER: Van den Bruel A 

PROVIDER: S-EPMC10169799 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature