Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators.

ABSTRACT: Along with different life strategies, organisms have evolved dramatic cellular composition differences. Understanding the molecular basis and fitness effects of these differences is key to elucidating the fundamental characteristics of life. TOR/insulin pathways are key regulators of cell size, but whether their activity determines cell size in a systemic or tissue-specific manner awaits exploration. To that end, we measured cells in four tissues in genetically modified Drosophila melanogaster (rictor^Δ2 and Mnt¹) and corresponding controls. While rictor^Δ2 flies lacked the Rictor protein in TOR complex 2, downregulating the functions of this element in TOR/insulin pathways, Mnt¹ flies lacked the transcriptional regulator protein Mnt, weakening the

SUBMITTER: Privalova V 

PROVIDER: S-EPMC10169805 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature